A case of acquired hemophilia associated with pemphigoid treated with factor eight inhibitor bypassing activity therapy
نویسندگان
چکیده
منابع مشابه
Acquired hemophilia associated with bullous pemphigoid: a case report.
The development of factor VIII inhibitors in non-hemophilic patients is rare and may occur in healthy individuals, mostly elderly and women in postpartum period, and in patients with malignant neoplasia or autoimmune diseases, such as bullous pemphigoid. We described the case of a 60-year-old female patient who developed bullous pemphigoid for 3 month and presented with bleeding tendency and he...
متن کاملBullous pemphigoid associated with acquired hemophilia
daily for 1 week), pulse therapy with methylprednisolone (1000 mg/day for 3 days) and rituximab (100 mg/week for 2 weeks) were initially used for correcting the coagulopathy. Prednisolone (1 mg/kg/day) and cyclophosphamide (100 mg/ day) were prescribed as maintenance therapy. The coagulatory disorder improved after 2 months of treatment associated with reduction of factor VIII inhibitor to 35 B...
متن کاملIdiopathic Acquired Hemophilia A with Undetectable Factor VIII Inhibitor
Objective. We present the case of a 73-year-old female, with no family or personal history of a bleeding disorder, who had a classic presentation for acquired hemophilia A. Factor VIII activity was low but detectable and a factor VIII inhibitor was undetectable. Methods. The patient's plasma was comprehensively studied to determine the cause of the acquired coagulopathy. Using the Nijmegen modi...
متن کامل[Acquired hemophilia A treated with rituximab. Report of one case].
We report a 54-year-old male presenting with a history or recurrent nose bleeds and ecchymoses. The coagulation study showed a prolonged partial thromboplastin time, a factor VIII of 8% and a high inhibitor titer (193 Bethesda units). A diagnosis of acquired hemophilia A was reached. The patient was initially treated with cyclophosphamide for seven months without response. Therefore rituximab i...
متن کاملAcquired Hemophilia A Successfully Treated with Rituximab
Acquired hemophilia A (AHA) is a rare bleeding disorder due to the development of specific autoantibodies against factor VIII. The anti-CD20 monoclonal antibody Rituximab has been proven to be effective in obtaining a long-term suppression of inhibitors of AHA, besides other immunosuppressive standard treatments. Here we describe a case of idiopathic AHA in a 60-year old man successfully treate...
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ژورنال
عنوان ژورنال: Journal of the Japanese Society of Intensive Care Medicine
سال: 2012
ISSN: 1340-7988,1882-966X
DOI: 10.3918/jsicm.19.389